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Isoelectric Point from Adjacent pKa Values Calculator — result sheet
Estimate the isoelectric point from the two pKa values that bracket the neutral zwitterion.
Inputs used
Results
Visual chart
Breakdown
Calculation steps
Returned data table
Formula and methodology
Formula: pI = (pKa,lower + pKa,upper)/2 for the two ionizations surrounding the neutral form.
The average is a model for compounds whose neutral zwitterionic form lies between the two entered ionization steps.
This result follows the calculator's declared inputs, precision, validation boundaries, and model limits.
Input contract
- Lower bracketing pKa — minimum 0; maximum 20
- Upper bracketing pKa — minimum 0; maximum 20
Worked example
| Input | Value |
|---|---|
| Lower bracketing pKa | 2.34 |
| Upper bracketing pKa | 9.6 |
Estimated pI = 5.97.
Assumptions and limits
- The entered pKa values are the adjacent ionizations that surround the neutral species.
- The pKa values use the same solvent, temperature, and convention.
- This shortcut is not used to choose pKas for every acidic or basic side-chain structure.
Calculator note
Source and methodology
Use the official WorldCalculate methodology policy for the source, formula, precision, and boundary standards behind this calculator.
Planning estimate, not financial, medical, legal, or professional advice. © WorldCalculate — reuse with attribution. Built and curated by Hassan ALRowaie.
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